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TRPC7 antisense RNA 1 (TRPC7-AS1)
- Target
- TRPC7-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
TRPC7 antisense RNA 1 (TRPC7-AS1) is a long non-coding RNA (lncRNA) transcribed from the antisense strand of the TRPC7 gene locus. It does not code for a protein and is classified as a non-protein coding RNA. TRPC7-AS1 is notably upregulated in hepatitis B virus-related hepatocellular carcinoma (HCC), where it has been proposed as a potential therapeutic target or diagnostic biomarker. Its expression is also associated with kidney clear cell sarcoma. Functional data suggest a possible role in the regulation of gene expression and epigenetic modification (such as m6A RNA methylation), but it is not currently classified as a druggable therapeutic target like receptors, enzymes, or ion channels. No direct drug interactions or mechanism-of-action data are available for TRPC7-AS1 at this time. It is not the TRPC7 protein or channel itself, but its antisense RNA, and should not be confused with ion channel targets[3][5][6].
- Other names
- TRPC7 antisense RNA 1 (non-protein coding)TRPC7-AS1ENSG00000248211 (Ensembl)Gene ID: 100874024 (NCBI)
02
Biological functions
Regulation of gene expressionEpigenetic modulation (N6-methyladenosine modification)Possible involvement in cellular signaling pathways (inferred from association with TRPC7 locus)
03
Disease associations
Cancer (notably hepatitis B virus-related hepatocellular carcinoma, kidney clear cell sarcoma)Other
04
Biomarkers
Potential diagnostic marker for hepatitis B virus-related hepatocellular carcinomaPossible biomarker for kidney clear cell sarcoma (by association)
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