TRPM8 channel associated factor 1 pseudogene 1 (TCAF1P1)

TRPM8 channel associated factor 1 pseudogene 1 (TCAF1P1) is classified as a processed pseudogene in humans, located on chromosome 7[4][9]. Unlike its functional paralog TCAF1, TCAF1P1 does not encode a protein and is not transcribed at levels that suggest biological activity[2][7]. Pseudogenes such as TCAF1P1 are often evolutionary remnants with mutations (such as stop codons and frame shifts) that prevent them from producing functional proteins[5][8]. They are generally not considered biological or therapeutic targets unless new evidence emerges for regulatory RNA activity, which is not reported for TCAF1P1. For reference: - TCAF1 (TRPM8 channel associated factor 1) is a protein-coding gene and does regulate the TRPM8 ion channel, influencing cellular functions like anion channel transport and cell migration inhibition, and is under investigation in cancer and other contexts[1][3][10]. TCAF1P1, however, shares sequence similarity but is not a functional copy[2][4][7][9].

Other names

FAM115B

None.