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Trypanosoma spp.
- Molecular classification
- Protozoan parasite, Kinetoplastida
01
Overview
Trypanosoma is a genus of unicellular, flagellated protozoan parasites responsible for significant human and animal diseases, including African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease). They exhibit complex life cycles involving vertebrate hosts and invertebrate vectors, and employ sophisticated immune evasion mechanisms such as VSG switching and trans-sialidase activity.
- Other names
- Trypanosoma bruceiTrypanosoma cruziAfrican trypanosomesAmerican trypanosomes
02
Biological functions
ParasitismReplication within hostImmune evasionTransmission via vectors
03
Disease associations
African trypanosomiasis (sleeping sickness)Chagas diseaseAnimal trypanosomiasis (nagana)
04
Safety considerations
Drug resistanceComplex life cycle complicates drug targetingAntigenic variation limits vaccine developmentHigh toxicity of some existing drugs
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