Target intelligence / Profile preview

Trypsin-like Serine Proteases (TLPs)

Target: TLPs
Molecular classification: Enzyme, Protease, Serine Protease, MEROPS Clan PA / Family S1

Overview

Trypsin-like serine proteases are a major subgroup of serine proteases characterized by their substrate specificity for cleaving after lysine or arginine residues. They possess a conserved catalytic triad (Ser195-His57-Asp102) and are involved in diverse physiological processes including digestion, coagulation, and immunity. These enzymes are classified within MEROPS Clan PA, Family S1. Inhibitors and activity-based probes are used for research and therapeutic purposes.

Mechanism of action

Inhibition of serine protease activity via binding to the active site, preventing substrate binding and peptide bond cleavage.

Biological functions

DigestionBlood coagulationComplement system activationImmune cell functionTissue remodeling

Disease associations

CancerInflammationThrombosisImmune disorders

Safety considerations

Off-target effects due to structural similarity with other serine proteasesPotential for bleeding complications with inhibitors of coagulation factors

Interacting drugs

Trypsin inhibitors

3 more in the full profile.

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