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Trypsinogen
- Molecular classification
- Zymogen, Proenzyme, Serine protease precursor
01
Overview
Trypsinogen is the inactive precursor (zymogen) of trypsin, a key digestive enzyme. It is synthesized and secreted primarily by the pancreas. It is activated by enteropeptidase in the small intestine to form trypsin, which then activates other digestive enzymes. Elevated levels of trypsinogen can be indicative of pancreatic injury or cystic fibrosis.
- Other names
- ProtrypsinTrypsin precursorCationic trypsinogen (trypsinogen-1)Anionic trypsinogen (trypsinogen-2)Mesotrypsinogen (trypsinogen-3)Brain-type trypsinogen (trypsinogen-4)
02
Biological functions
Precursor for protein digestionActivation of pancreatic zymogensPrevention of pancreatic autodigestion
03
Disease associations
PancreatitisCystic fibrosisPancreatic cancer
04
Safety considerations
Premature activation leading to autodigestion of the pancreasPotential for chronic inflammation and fibrosis
05
Biomarkers
Elevated trypsinogen levels in blood indicate pancreatic injuryElevated immunoreactive trypsinogen in newborns indicates cystic fibrosis
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