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Target intelligence / Profile preview
Mast Cell Tryptase (Tryptase)
- Target
- Tryptase
- Molecular classification
- Serine Protease, Enzyme
01
Overview
Mast cell tryptase is a neutral serine protease and the most abundant mediator stored in mast cell granules. It plays a central role in inflammatory and immediate allergic reactions, functioning as a specific marker for mast cell activation and degranulation. It is involved in airway homeostasis, vascular relaxation and contraction, gastrointestinal smooth muscle activity, intestinal transport, coagulation, angiogenesis, and neuropeptide modulation. Elevated levels are associated with various conditions, including anaphylaxis, mast cell disorders, hematological conditions, and cancer. It is a potential therapeutic target for allergic and inflammatory diseases, cancer, and mast cell disorders.
- Other names
- Tryptase-alphaTryptase-beta
02
Mechanism of action
Tryptase inhibitors (under development)
03
Biological functions
Inflammation regulationReceptor activationTissue homeostasisInflammatory amplificationTissue remodelingAngiogenesisNeuropeptide modulationMast cell activation
04
Disease associations
AnaphylaxisMast cell disordersSystemic mastocytosisCutaneous mastocytosisMast cell activation syndromeAllergic conditionsHematological conditionsCancerAsthmaChronic kidney diseaseObesity
05
Safety considerations
Potential for off-target effects due to the broad substrate specificity of tryptase.Incomplete inhibition of tryptase activity.
06
Biomarkers
Anaphylaxis diagnosisMast cell disorder diagnosisDisease progression monitoring
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