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Tryptophan 5-hydroxylase 2 (None)

Target: None
Molecular classification: Enzyme, Biopterin-dependent aromatic amino acid hydroxylase

Overview

Tryptophan 5-hydroxylase 2 (TPH2) is a neuron-specific isoform of tryptophan hydroxylase, the rate-limiting enzyme in serotonin biosynthesis. It catalyzes the conversion of L-tryptophan to 5-hydroxytryptophan (5-HTP) in the brain. Serotonin synthesized via this pathway plays critical roles in mood regulation, stress response, aggression control, and sleep-wake cycles. Genetic variations affecting its activity are associated with psychiatric disorders.

Other names: Neuronal tryptophan hydroxylaseNTPHADHD7EC 1.14.16.4FLJ37295MGC138872

Mechanism of action

Inhibition of serotonin synthesis

Biological functions

Serotonin biosynthesisMood regulationStress response modulationAggression controlSleep-wake cycle regulation

Disease associations

Major depressive disorderDepressive disordersBipolar affective disorder

Safety considerations

Pharmacological inhibition or genetic impairment leads to reduced brain serotonin levels which may alter mood/behavior.

Interacting drugs

p-chlorophenylalanine (PCPA)

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