Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tryptophan Hydroxylase 2 (None)
- Target
- None
- Molecular classification
- Enzyme, Aromatic amino acid hydroxylase
01
Overview
Tryptophan hydroxylase 2 (TPH2) is an enzyme that catalyzes the rate-limiting step in the biosynthesis of serotonin in the central nervous system. It is a member of the aromatic amino acid hydroxylase superfamily and is distinct from TPH1, which operates primarily in peripheral tissues. Mutations or polymorphisms in TPH2 are associated with various psychiatric disorders including depression, anxiety disorders, aggression-related behaviors, obsessive-compulsive disorder (OCD), schizophrenia, catalepsy, and other stress-related conditions.
- Other names
- TPH2
02
Mechanism of action
Pharmacological chaperones (for stabilizing mutant forms); Inhibitors (for reducing excess activity)
03
Biological functions
Serotonin biosynthesisRegulation of moodRegulation of sleepRegulation of appetiteStress response
04
Disease associations
DepressionAnxiety disordersObsessive-compulsive disorder (OCD)SchizophreniaCatalepsyAggression-related behaviors
05
Safety considerations
Potential for off-target effectsRisk of serotonin syndrome with inhibitorsGenetic variability affecting drug response
Beyond the preview
Go deeper on Tryptophan Hydroxylase 2 (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tryptophan Hydroxylase 2 (None).