TSR2 ribosome maturation factor (TSR2)

TSR2 ribosome maturation factor is a highly conserved protein involved in eukaryotic ribosome biogenesis, specifically acting as a chaperone—also termed an escortin—for the ribosomal protein eS26 (Rps26)[1][2][3]. After ribosomal proteins are imported into the nucleus, TSR2 mediates the dissociation of eS26 from its nuclear importins by a RanGTP-independent mechanism, shields it from aggregation and proteolysis, and traffics it to the pre-ribosomal 90S complex during the early stages of ribosome assembly[1][2]. TSR2 can also extract Rps26 from mature ribosomes under certain stress conditions, temporarily storing it to allow ribosome remodeling and repair, thereby facilitating cellular adaptation to stress[2]. In yeast and humans, depletion or mutation of TSR2 leads to defects in ribosome maturation, reduced cell growth, and is linked functionally (but not genetically) to Diamond-Blackfan anemia through its client protein eS26[1][2][3]. TSR2 does not belong to any classical druggable target class (receptor, enzyme, transporter), and there are as yet no recognized drugs or therapeutic programs targeting this factor.

Other names

DT1P1A10WGG1DBA14ribosome maturation factor TSR2