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Target intelligence / Profile preview
TSSK6-activating co-chaperone protein (TSACC)
- Target
- TSACC
- Molecular classification
- Other (Co-chaperone, not an enzyme, receptor, transporter, transcription factor, or ion channel)
01
Overview
TSSK6-activating co-chaperone protein (TSACC) is a cytoplasmic protein that serves as a co-chaperone, directly binding to both HSP70 and TSSK6, and associates with HSP90[4][1][3]. TSACC selectively facilitates HSP90-mediated activation of the testis-specific serine/threonine kinase TSSK6 (also known as SSTK), playing a key role in the stabilization, folding, and activation of TSSK6 during spermiogenesis[1][2][4]. This function is thought to be specific for post-meiotic male germ cells, where correct activation of TSSK6 is essential for male fertility in mammals[1]. There is no clear evidence that TSACC serves as a direct therapeutic target, nor is it currently associated with any known drug interactions, biomarker status, or specific safety risks.
- Other names
- C1orf182SIPSSTK-IPSSTK-interacting proteinTSSK6 activating cochaperone
02
Mechanism of action
Not applicable; no drugs currently target TSACC
03
Biological functions
Chaperone bindingfacilitates HSP (heat shock protein)-mediated activation of TSSK6protein folding
04
Disease associations
Other (no major or direct disease role established; potential connection to reproductive biology and possibly male fertility per TSSK6 pathway involvement)
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