TTC21B antisense RNA 1 (TTC21B-AS1)

TTC21B antisense RNA 1 (TTC21B-AS1) is a human long non-coding RNA (lncRNA) gene located on chromosome 2, on the positive strand, in close proximity to the protein-coding gene TTC21B[1][3][7]. As an antisense RNA, it is thought to potentially regulate the expression of its sense counterpart (TTC21B), but its biological function remains largely uncharacterized[5]. TTC21B-AS1 is referenced in several genetic disease databases as being genetically associated with nephronophthisis 12 and short-rib thoracic dysplasia 4, both ciliopathies, but mechanistic or causal roles are not established[4][7]. There are no known drugs or small molecules directly targeting this lncRNA, and it is not currently considered a therapeutic target. Accordingly, TTC21B-AS1 is primarily classified as a long non-coding antisense RNA with currently limited functional annotation.

Not applicable (no known targeted drugs or interventions)