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Target intelligence / Profile preview
Tubulin alpha-1A chain (TUBA1A)
- Target
- TUBA1A
- Molecular classification
- Tubulin, Cytoskeletal protein
01
Overview
Tubulin alpha-1A chain is a protein that forms part of the microtubules, which are crucial components of the cytoskeleton. It is particularly important for neural development through its role in neuronal migration. Mutations in this protein lead to severe neurodevelopmental disorders, notably lissencephaly, due to impaired cortical formation.
- Other names
- B-ALPHA-1LIS3TUBA3tubulin alpha 3 chaintubulin B-alpha-1hum-a-tub1hum-a-tub2
02
Mechanism of action
Microtubule disruption (polymerization or depolymerization inhibition)
03
Biological functions
Microtubule assemblyCell shape maintenanceIntracellular transportMitosisNeuronal migration
04
Disease associations
Isolated Lissencephaly Sequence (ILS)Lissencephaly Type 3 (LIS3)Neurodevelopmental disorders
05
Safety considerations
NeurotoxicityMyelosuppressionDrug resistance
06
Interacting drugs
Taxol
4 more in the full profile.
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