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Tubulin alpha-3C chain (TUBA3C)
- Target
- TUBA3C
- Molecular classification
- Cytoskeletal protein, Structural protein, Tubulin family
01
Overview
Tubulin alpha-3C chain (TUBA3C) is a major structural protein of microtubules, essential cytoskeletal filaments in eukaryotic cells. Microtubules are involved in cell division, intracellular transport, and maintaining cell shape. TUBA3C represents an alpha-tubulin isotype and forms heterodimers with beta-tubulin to build microtubules. It binds nucleotides (GTP/GDP), exhibits GTPase activity, and is ubiquitously involved in the formation of the cytoskeleton. Genetic variations in TUBA3C are associated with several cancers and rare syndromes. As a member of the tubulin family, it is targeted by various antimitotic drugs commonly used in cancer therapy, which disrupt microtubule dynamics to inhibit cell proliferation[1][2][3][8].
- Other names
- Tubulin alpha-3D chainTubulin alpha-2 chainTubulin alpha-3C/D chainAlpha-tubulin 3CAlpha-tubulin 3DAlpha-tubulin 2TUBA2bA408E5.3Detyrosinated tubulin alpha-3C chain
02
Mechanism of action
Inhibition of microtubule polymerization (vinca alkaloids, colchicine); Stabilization of microtubules (taxanes such as paclitaxel, docetaxel)
03
Biological functions
Structural constituent of cytoskeletonMicrotubule polymerizationCell divisionIntracellular transport
04
Disease associations
Cancer (bladder cancer, lung cancer, ovarian cancer, breast cancer, thyroid cancer, head and neck carcinoma, peritoneal carcinoma, fallopian tube neoplasms)Genetic syndromes (Clouston hidrotic ectodermal dysplasia, Kabuki syndrome, Teebi hypertelorism syndrome)NeutropeniaSchizophrenia
05
Safety considerations
Peripheral neuropathy (due to disruption of microtubule function by drugs)MyelosuppressionDrug resistance (e.g., tubulin mutations can confer resistance to antimicrotubule agents)
06
Interacting drugs
Colchicine
3 more in the full profile.
07
Biomarkers
Expression of tubulin alpha-3C in tumor tissue (potential for use as a biomarker in various cancers; class effect for tubulins, not unique to TUBA3C)
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