Tubulin alpha-3E chain (TUBA3E)

Tubulin alpha-3E chain is a **highly conserved alpha-tubulin isoform** that constitutes one half of the heterodimeric tubulin complex, the primary structural component of eukaryotic microtubules. Microtubules are essential for cellular processes including mitosis, intracellular transport, and maintenance of cell shape. TUBA3E is expressed in various tissues and, like other tubulins, polymerizes with beta-tubulin to form dynamic microtubule filaments. Mutations in TUBA3E are associated with disorders such as primary microcephaly and Seckel syndrome, highlighting its essential developmental role. Tubulin family proteins are established targets for many anti-mitotic and anti-cancer therapeutics; however, most approved drugs target tubulin broadly without isoform selectivity, so while TUBA3E is a structural component of the pharmacological target, few interventions are specific to this isoform alone[1][3][2][4].

Other names

Tubulin alpha-3ETubulin alpha 3eTUBA3EAlpha-tubulin 3EDetyrosinated tubulin alpha-3E chain

Microtubule polymerization/depolymerization inhibition Disruption of microtubule dynamics leading to mitotic arrest and apoptosis (typical for drugs like paclitaxel, colchicine, vincristine targeting tubulin)