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Tubulin alpha-4A chain
- Molecular classification
- Tubulin, Structural protein
01
Overview
Tubulin alpha-4A chain is a member of the tubulin superfamily and a major component of microtubules. It forms heterodimers with beta-tubulin, which polymerize to form microtubules. Microtubules are essential for cell structure, intracellular transport, and cell division. TUBA4A is involved in diverse cellular processes, including mitosis, intracellular trafficking, and maintenance of cell shape. Mutations or dysregulation in tubulins, including TUBA4A, can contribute to diseases like ALS. It interacts with proteins like NCOA6 and APC, linking it to cell signaling and cancer-related pathways.
- Other names
- H2-alphaTUBA1ALS22Tubulin alpha 4a
02
Mechanism of action
Microtubule disruption (for tubulin-targeting agents generally, not specific to TUBA4A)
03
Biological functions
Microtubule assemblyStructural supportMitosis/meiosisIntracellular traffickingCell shape maintenanceOrganelle positioning
04
Disease associations
Amyotrophic Lateral Sclerosis (ALS)Neurodegenerative diseasesCancer (potentially through APC interaction)
05
Safety considerations
Potential for off-target effects due to tubulin's widespread role in cellular processes.Toxicity associated with microtubule disrupting agents (for tubulin-targeting agents generally, not specific to TUBA4A)
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