Tubulin alpha pseudogene 7 (TUBAP7)

Tubulin alpha pseudogene 7 (TUBAP7) is a non-coding genomic sequence annotated as a pseudogene in the tubulin alpha family. Pseudogenes such as TUBAP7 are non-functional remnants of gene duplication or retrotransposition events, sharing sequence similarity with functional alpha-tubulin genes but lacking protein-coding potential due to disabling mutations or truncation. Unlike functional tubulin alpha genes, which encode proteins that shape microtubules and are implicated in neurological disease and targeted by drugs[1][2], TUBAP7 has no direct biological function, disease association, nor therapeutic relevance. Its presence is relevant only for evolutionary or genomic reference, not for pharmacological targeting. Critical context: - While some protein-coding tubulin alpha genes (e.g., TUBA1A) are important cytoskeletal proteins and are involved in diseases such as lissencephaly and are targets for anti-microtubule drugs[1][2], TUBAP7 is not among those and does not encode a protein product. - Pseudogenes are sometimes transcribed, but their RNAs typically have no biological function or clinical use. - The inclusion of TUBAP7 as a therapeutic "target" or biomarker is incorrect based on current scientific criteria[3].

Other names

Tubulin alpha 4a pseudogeneTUBAP7

None (pseudogenes are not targeted by drugs as they do not produce targetable proteins)