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Target intelligence / Profile preview
Tubulin Alpha Subunit (TUBA)
- Target
- TUBA
- Molecular classification
- Structural Protein, Cytoskeletal Protein
01
Overview
The tubulin alpha subunit is a highly conserved protein that forms heterodimers with beta-tubulin, the fundamental building blocks of microtubules. Microtubules are dynamic cytoskeletal filaments essential for cell structure, intracellular transport, and cell division. Alpha-tubulin plays a critical role in these processes and is particularly important in neuronal development and migration. It is a target for anticancer drugs like taxanes, which disrupt microtubule dynamics.
- Other names
- alpha-tubulinTUBalpha
02
Mechanism of action
Microtubule stabilization or destabilization leading to mitotic arrest.
03
Biological functions
Microtubule assemblyCytoskeleton organizationIntracellular transportCell divisionNeuronal migrationStructural support
04
Disease associations
CancerNeurodevelopmental disorders
05
Safety considerations
NeurotoxicityMyelosuppression (for drugs targeting tubulin)
06
Interacting drugs
Taxanes (e.g., Paclitaxel)
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