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Target intelligence / Profile preview
Tubulin beta-1 chain (TUBB1)
- Target
- TUBB1
- Molecular classification
- Structural protein, Cytoskeletal protein, GTPase
01
Overview
Tubulin beta-1 chain is a major structural component of microtubules, essential for cell shape, intracellular transport, and mitosis. It forms heterodimers with alpha-tubulins, playing critical roles in microtubule dynamics and spindle assembly. Mutations can affect platelet production and function. The colchicine binding site makes it a target for anti-mitotic cancer drugs.
- Other names
- Tubulin beta 1 class VIMACTHC1
02
Mechanism of action
Inhibition of microtubule polymerization
03
Biological functions
Microtubule polymerization/depolymerizationSpindle formationCytoskeletal organizationIntracellular transportPlatelet biogenesis
04
Disease associations
CancerPlatelet disorders
05
Safety considerations
Off-target effects of tubulin inhibitorsDrug resistance
06
Interacting drugs
Colchicine
1 more in the full profile.
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