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Target intelligence / Profile preview
Tubulin beta-4A chain (TUBB4A)
- Target
- TUBB4A
- Molecular classification
- Structural protein, Cytoskeletal protein, Microtubule component
01
Overview
Tubulin beta-4A chain is a protein encoded by the *TUBB4A* gene and is a member of the tubulin family, which forms microtubules—key structural components of the cytoskeleton. It plays critical roles in cell shape, intracellular transport, cell division, neuronal migration, and myelination, particularly in the central nervous system. Mutations in *TUBB4A* are linked to several neurological disorders, including hypomyelination syndromes and dystonia.
- Other names
- DYT4TUBB4TUBB5beta-5tubulin beta 4A class IVa
02
Mechanism of action
Microtubule disruption (inferred from general tubulin targeting drugs)
03
Biological functions
Microtubule formationCell shape maintenanceIntracellular transportCell divisionNeuronal migrationWhite matter integrity maintenanceMyelination supportMitotic cell cycle progressionOrganelle organizationProtein folding
04
Disease associations
Hypomyelination with Atrophy of Basal Ganglia and Cerebellum (H-ABC)Hereditary Whispering Dysphonia (DYT4)Pelizaeus–Merzbacher DiseaseEpileptic encephalopathy with hypomyelinated leukodystrophy
05
Safety considerations
Neurological side effects (inferred from associated diseases)Potential for developmental toxicity
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