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Target intelligence / Profile preview
Tubulin beta-8 chain (TUBB8)
- Target
- TUBB8
- Molecular classification
- Other (Cytoskeletal protein, Microtubule component)
01
Overview
Tubulin beta-8 chain (TUBB8) is a primate-specific beta-tubulin isotype that constitutes the major beta-tubulin subunit in human oocytes and early embryos. It is essential for microtubule network formation, meiotic spindle assembly, and normal oocyte maturation. Genetic defects in TUBB8 result in female infertility due to meiotic arrest and have been identified as the cause of oocyte/zygote/embryo maturation arrest syndromes[1][2][3][4][6][7].
- Other names
- Tubulin beta 8 class VIIIclass VIII beta-tubulinbA631M21.2OOMD2OOMDOZEMA2HSA10p15 beta-tubulin 4QTUBB8
02
Mechanism of action
Not applicable (no known drug interactions)
03
Biological functions
Microtubule assemblyMeiotic spindle formationOocyte maturationEarly embryonic development
04
Disease associations
Female infertility due to oocyte meiotic arrestOocyte/zygote/embryo maturation arrest 2
05
Safety considerations
No major therapeutic safety concerns reported; defects cause infertility, not known to be drug-targeted
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