Target intelligence / Profile preview

Tubulin Beta Chain Protein Family (TUBB)

Target: TUBB
Molecular classification: Tubulin, GTPase, Cytoskeletal protein

Overview

Tubulin beta chains are a family of proteins that, together with alpha tubulins, form the heterodimeric building blocks of microtubules. Microtubules are cylindrical polymers essential for cell shape, intracellular transport, chromosome segregation during mitosis and meiosis, and other cellular processes. Multiple genes encode different β-tubulin isoforms in humans, each with distinct tissue expression patterns and functional roles. Mutations or dysregulation in specific beta tubulins can cause disease. Many anti-cancer drugs target beta tubulins due to their role in mitosis.

Other names: β-tubulinBeta TubulinTUBB1TUBB4ATUBB2ATUBB2BTUBB2CTUBB2DTUBB2ETUBB2FTUBB2GTUBB2H

Mechanism of action

Drugs bind to β-tubulin and interfere with microtubule dynamics, disrupting cell division and other microtubule-dependent processes.

Biological functions

Cell divisionSpindle formationChromosome movementIntracellular traffickingMaintenance of cell shapeCilia/flagella structureMicrotubule dynamics

Disease associations

Dystonia type 4HABC leukoencephalopathyPlatelet formation disordersCancer

Safety considerations

NeurotoxicityMyelosuppressionResistance development

Interacting drugs

Paclitaxel

4 more in the full profile.

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