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Target intelligence / Profile preview
Tubulin Beta Subunit (TUBB)
- Target
- TUBB
- Molecular classification
- Structural Protein, Cytoskeletal Protein, Tubulin
01
Overview
The tubulin beta subunit is a core component of microtubules, essential cytoskeletal structures involved in cell shape, intracellular transport, and cell division. It heterodimerizes with alpha-tubulin to form the building blocks of microtubules. Several beta-tubulin isotypes exist, exhibiting tissue-specific expression and functional specialization. Beta-tubulin is a major target for anti-cancer drugs, which disrupt microtubule dynamics, inhibiting cell proliferation.
- Other names
- Beta TubulinTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8
02
Mechanism of action
Disruption of microtubule dynamics, leading to cell cycle arrest and apoptosis.
03
Biological functions
Microtubule assemblyCell structure maintenanceIntracellular transportCell divisionChromosome segregationSignal transduction
04
Disease associations
CancerNeurodegenerative diseaseChemotherapy resistanceCilia dysfunctionDevelopmental disorders
05
Safety considerations
Neurotoxicity (e.g., paclitaxel-induced peripheral neuropathy)Myelosuppression (e.g., vinblastine)Drug resistance (e.g., mutations in tubulin genes)Off-target effects on normal cells
06
Interacting drugs
Paclitaxel
5 more in the full profile.
07
Biomarkers
TUBB3 expression in cancer cells (prognostic and predictive)Mutations in TUBB genes associated with specific diseasesTubulin isotype expression levels
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