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Target intelligence / Profile preview
Tubulin epsilon and delta complex protein 1 (TEDC1)
- Target
- TEDC1
- Molecular classification
- Other (complex-forming centriolar protein)
01
Overview
Tubulin epsilon and delta complex protein 1 (TEDC1) is a protein localized to centrioles, functioning as a critical positive regulator of ciliary hedgehog signaling and essential for centriole stability[1][2][6]. TEDC1 physically interacts with TEDC2, delta-tubulin (TUBD1), and epsilon-tubulin (TUBE1), forming a tetrameric complex fundamental for centriole structure and assembly[2][3][6]. Loss of TEDC1 phenocopies the loss of delta-tubulin and epsilon-tubulin (aberrant centrioles, lacking triplet microtubules, and prone to disintegration), reflecting its direct role in architectural maintenance—not signaling or catalysis[2][4]. While associated with some congenital diseases such as lacrimal duct obstruction and microcephaly, TEDC1 is not exploited as a drug target nor is it a recognized biomarker or therapeutic safety concern[1]. Its primary biological role is in the foundational assembly and function of centrioles and cilia in eukaryotic cells[2][5].
- Other names
- TEDC1C14orf80uncharacterized protein C14orf80tubulin epsilon and delta complex protein 1
02
Mechanism of action
None established; TEDC1 is not a pharmacological target
03
Biological functions
Positive regulation of ciliary hedgehog signalingRequired for centriole stabilityRegulation of triplet microtubule formation and centriole architectureCounteracting perturbation of actin filaments
04
Disease associations
Associated with Lacrimal duct obstructionAssociated with Primary autosomal recessive microcephalyNo direct disease-target role established; it is involved in maintaining cell architecture rather than directly mediating disease
05
Safety considerations
None described; as a structural/assembly protein, disrupting TEDC1 leads to centriole and ciliary dysfunction, but not characterized as a safety marker in therapy or drug development
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