Tubulin-folding cofactor B (TBCB)

Tubulin-folding cofactor B (TBCB) is a molecular chaperone involved in the biogenesis and regulation of α/β-tubulin heterodimers, acting downstream of cytosolic chaperonins to bind α-tubulin folding intermediates and guide proper tubulin assembly. TBCB forms complexes with other tubulin-folding cofactors, especially TBCE, regulating both the folding and dissociation of tubulin heterodimers. These activities are essential for microtubule organization, cell integrity, and proper cell division and growth. Disruption or altered expression of TBCB is associated with disorders of cytoskeletal dynamics, neurodevelopment, and diseases such as Kenny-Caffey syndrome[1][2][3][6][7].

Other names

Cytoskeleton-associated protein 1CKAP1CKAPITubulin-specific chaperone BCG22

Tubulin folding cofactors like TBCB participate in the biogenesis and homeostasis of tubulin dimers and can modulate microtubule stability, potentially affecting sensitivity to microtubule-modulating drugs like paclitaxel.