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Tubulin Polymerisation

Molecular classification: Other

Overview

Tubulin polymerisation refers to the process by which tubulin proteins (specifically α- and β-tubulin) assemble into microtubules, a key component of the eukaryotic cytoskeleton. This dynamic process is essential for cell structure, intracellular transport, and chromosome segregation during mitosis. Agents that inhibit this process can arrest cell division by preventing proper spindle formation.

Mechanism of action

Disruption or stabilization of tubulin polymerisation.

Biological functions

Cell cycleCell shape maintenanceIntracellular trafficking

Disease associations

Cancer

Interacting drugs

Colchicine

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