Tubulin polymerisation process

Tubulin is a highly conserved protein that forms heterodimers (α- and β-tubulin) assembling into dynamic microtubules, key structural elements of the cytoskeleton[3][4][6]. The tubulin polymerisation process is essential for cell division, intracellular transport, and maintenance of cell architecture. This process is the primary target of several therapeutic agents, especially antimitotic anticancer drugs, which disrupt microtubule dynamics to arrest cell cycle progression and induce cell death. Inhibition or aberrant regulation of tubulin polymerisation is also involved in the pathophysiology of neurodegenerative and infectious diseases[3][4][6].

Other names

Microtubule proteinβ-tubulin and α-tubulin heterodimerTubulin dimer

Inhibition of tubulin polymerisation (e.g., colchicine, vincristine) Stabilisation of microtubules (e.g., paclitaxel) Disruption of microtubule dynamics causing mitotic arrest and apoptosis