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Tubulin polymerization protein subunit beta class I
- Molecular classification
- Tubulins, Structural Protein, Cytoskeletal Protein
01
Overview
Tubulin polymerization protein subunit beta class I (TUBB) is a key component of microtubules, which are essential for cell division, intracellular transport, and cell shape. It is a major drug target for anti-mitotic chemotherapeutics like paclitaxel, colchicine and vinca alkaloids, which disrupt microtubule dynamics and spindle formation, leading to apoptosis of rapidly dividing cells. Mutations in TUBB can disrupt vesicle trafficking or alter microtubule dynamics, leading to disease phenotypes.
- Other names
- TUBBbeta1-tubulintubulin beta 5 class ITubbin Beta Class ITubbin Beta 5 Class I
02
Mechanism of action
Inhibition of tubulin polymerization, disruption of microtubule dynamics, disruption of spindle formation during cell division
03
Biological functions
Microtubule assembly/disassemblyIntracellular traffickingChromosome segregationCell divisionMaintenance of cell shape
04
Disease associations
CancerGenetic Disorders (due to mutations affecting microtubule dynamics or vesicle trafficking)
05
Safety considerations
Drug resistance (due to mutations in TUBB)Off-target effects of tubulin-targeting drugsNeurotoxicity (for some tubulin inhibitors)Myelosuppression (for some tubulin inhibitors)
06
Interacting drugs
Paclitaxel
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