Target intelligence / Profile preview

Tubulin-specific chaperone E (TBCE)

Target: TBCE
Molecular classification: Molecular chaperone, Protein-folding factor, Other

Overview

Tubulin-specific chaperone E (TBCE) is a protein involved in the second step of the tubulin folding pathway, essential for the correct folding of beta-tubulin and regulation of tubulin heterodimer dissociation[2][3][5]. TBCE works in concert with other cofactors (A, C, D, E) to ensure the proper assembly, stability, and turnover of microtubules—a process critical for cellular functions such as mitosis, intracellular transport, and maintenance of the neuronal microtubule network[1][5][6]. Mutations in TBCE are linked to rare syndromic diseases involving parathyroid dysfunction, neurodevelopmental issues, and skeletal anomalies[2][3]. TBCE is not currently a direct pharmacological target for approved drugs but may intersect with tubulin-targeting agents via its role in tubulin biogenesis[1][3].

Other names: Tubulin folding cofactor EKCS1pac2HRDKCSPEAMOTBCETubulin-folding cofactor ETubulin-specific chaperone E

Biological functions

Protein foldingMicrotubule cytoskeleton organizationRegulation of tubulin heterodimer dissociationMaintenance of neuronal microtubule networkRegulation of mitotic spindle formation

Disease associations

Hypoparathyroidism-retardation-dysmorphism syndrome (HRD, Sanjad-Sakati syndrome)Kenny-Caffey syndrome, type 1Other

Safety considerations

Disruption of TBCE function can impair microtubule organization and neuronal maintenance, which may contribute to syndromic developmental disorders such as HRD and Kenny-Caffey syndrome, but drug-specific safety challenges are not reported[2][3]

Interacting drugs

Paclitaxel (interaction is indirect, as paclitaxel affects tubulin dynamics and TBCE is involved in tubulin biogenesis, but TBCE is not a direct pharmacological target of known drugs)[1]

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