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Tubulin Subunit Alpha (α-tubulin)

Target: α-tubulin
Molecular classification: Cytoskeletal protein, Tubulin

Overview

Tubulin subunit alpha is one of the two main protein components that form microtubules, essential cytoskeletal structures in eukaryotic cells. Microtubules are dynamic, hollow cylinders composed of linear protofilaments made from repeating α- and β-tubulin heterodimers. These structures provide mechanical support, serve as tracks for intracellular transport, and play critical roles in cell division and other cellular processes. It is a validated target for anti-cancer drugs due to its central role in mitosis.

Other names: Alpha-tubulinTubulin alpha chain

Mechanism of action

Microtubule stabilization or destabilization

Biological functions

Structural supportIntracellular transportMitosisCell shape maintenanceCiliogenesis

Disease associations

CancerNeurodegenerative disease (potential)Other (diseases related to cilia dysfunction)

Safety considerations

Neurotoxicity (Vinca alkaloids)Myelosuppression (Taxanes)Drug resistanceOff-target effects due to tubulin isoforms in different tissues

Interacting drugs

Taxanes

4 more in the full profile.

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