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Tubulin Subunit Beta (β-tubulin)
- Target
- β-tubulin
- Molecular classification
- Structural protein, Cytoskeletal protein, Tubulin
01
Overview
Tubulin subunit beta (β-tubulin) is a highly conserved protein that, together with alpha-tubulin (α-tubulin), forms heterodimers which are the fundamental building blocks of microtubules. Microtubules are dynamic cytoskeletal structures essential for maintaining cell shape, enabling intracellular transport, and facilitating cell division in all eukaryotic cells. β-Tubulin pairs with α-tubulin to form protofilaments that assemble into microtubules. Several drugs target specific sites on β-tubulin dimers to inhibit cell division. Altered expression or mutation of certain tubulin beta isoforms has been implicated in tumorigenesis, which has made tubulins key targets for chemotherapeutic drug development.
- Other names
- Beta TubulinTUBBTubulin beta chain
02
Mechanism of action
Microtubule stabilization or destabilization, leading to disruption of cell division and intracellular transport.
03
Biological functions
Microtubule assemblyStructural supportIntracellular transportMitosis/MeiosisCell shape maintenanceMotor protein binding
04
Disease associations
CancerNeurodevelopmental disordersDrug resistance
05
Safety considerations
Drug resistanceNeurotoxicity (for some tubulin-targeting agents)Myelosuppression (for some tubulin-targeting agents)Off-target effects due to tubulin's ubiquitous expression
06
Interacting drugs
Vinca alkaloids (e.g., Vinblastine, Vincristine)
6 more in the full profile.
07
Biomarkers
Expression levels of specific β-tubulin isoformsPost-translational modification patterns of β-tubulin
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