Tubulin tyrosine ligase like 13 (TTLL13)

TTLL13 (Tubulin tyrosine ligase like 13) is an ATP-dependent polyglutamylase enzyme that catalyzes the elongation phase of polyglutamylation on tubulin, mainly modifying the alpha-tubulin tail in the cytosol and ciliary basal bodies[3]. This modification affects microtubule dynamics and stability, influencing diverse cellular functions, including cell division, intracellular transport, and the formation of specialized structures such as cilia and flagella[2][3]. Dysfunction in tubulin polyglutamylases and related tubulin modifications is linked to cancer progression and neurodevelopmental disorders due to abnormal microtubule regulation[1][2]. TTLL13 is structurally related to other TTLL family enzymes and contains characteristic ATP-grasp domains that facilitate its catalytic activity[1][3].

Other names

Tubulin polyglutamylase TTLL13TTLL13TTLL13PFLJ46079MGC33417Tubulin tyrosine ligase-like family member 13 pseudogeneTubulin–tyrosine ligase-like protein 13