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Target intelligence / Profile preview
Tubulin tyrosine ligase-like 6 (TTLL6)
- Target
- TTLL6
- Molecular classification
- Enzyme (Polyglutamylase)
01
Overview
TTLL6 is a polyglutamylase enzyme that adds glutamate chains to tubulin and non-tubulin proteins, influencing microtubule dynamics and ciliary function. It is involved in the regulation of microtubule severing and plays a role in the formation and movement of cilia. Additionally, TTLL6 modifies the CGAS protein, affecting immune responses to viral infections. It is associated with several diseases involving cilial dysfunctions and is a potential target for therapeutic interventions related to microtubule regulation and ciliary pathologies.
- Other names
- Tubulin polyglutamylase TTLL6TTL.6FLJ35808Protein polyglutamylase TTLL6Tubulin--tyrosine ligase-like protein 6
02
Mechanism of action
Polyglutamylation of tubulin and non-tubulin proteins; Regulation of microtubule functions; Stimulation of spastin-mediated microtubule severing
03
Biological functions
Microtubule bundle formationProtein polyglutamylationRegulation of cilium beat frequency involved in ciliary motilityMicrotubule severingImmune response (via modification of CGAS)
04
Disease associations
Joubert Syndrome 33Meckel Syndrome, Type 1Hyperinsulinismexercise-induced hyperinsulinism3-hydroxy-3-methylglutaryl-CoA synthase deficiencyglycogen storage disorders
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