Tubulin tyrosine ligase-like family member 12 pseudogene (TTLL12P)

The **tubulin tyrosine ligase-like family member 12 pseudogene** is a non-functional DNA segment derived from TTLL12, a member of the tubulin tyrosine ligase-like family. Pseudogenes arise from gene duplication or retrotransposition followed by sequence mutations that disrupt protein coding ability. While some pseudogenes may be transcribed and play regulatory roles, the TTLL12 pseudogene has not been shown to have any functional protein-coding or regulatory activity. The functional TTLL12 protein is known to impact histone and tubulin modifications, regulating mitosis and chromosome number stability, but the pseudogene itself does not participate directly in these processes[1][4][5].\n\n**Key interpretation:**\n- The actual TTLL12 protein (not the pseudogene) has potential regulatory roles in tubulin and histone modification, but the pseudogene (ENSG00000271196) is not a target for therapeutic intervention, does not encode a receptor, enzyme, transporter, or other druggable entity, and is only relevant as a genomic/annotation artifact[2][4][5].

Other names

Tubulin tyrosine ligase-like family member 12 pseudogeneTTLL12PTTLL12 pseudogene

None (no mechanism of action, as the pseudogene does not encode a protein)