Tubulin tyrosine ligase-like protein 11 (TTLL11)

Tubulin tyrosine ligase-like protein 11 (TTLL11) is an enzyme of the TTLL family responsible for catalyzing the polyglutamylation of microtubules, a post-translational modification that extends glutamate chains primarily on the α- and β-tubulin subunits[1][3]. TTLL11 acts preferentially as an elongase, directly increasing glutamate chain length rather than initiating lateral branching, a property that distinguishes it from other TTLL family members. Functionally, TTLL11 regulates microtubule dynamics critical for spindle assembly during mitosis and is essential for accurate chromosome segregation[3]. It also contributes to the maintenance of ciliary structure and function, with genetic variants implicated in diseases such as adolescent idiopathic scoliosis[2]. In the nervous system, TTLL11 expression influences cognitive processes, and genetic variation has been associated with attention performance[2]. Dysregulation of TTLL11 has been linked to cancer through impaired chromosome segregation and may play a role in neurodevelopmental disorders[3][2]. No drugs currently target TTLL11 directly, but the enzyme is of interest for its fundamental role in cytoskeletal regulation and disease pathology[1][2][3].

Other names

TTLL11Tubulin polyglutamylase TTLL11Tubulin tyrosine ligase-like family member 11C9orf20BA244O19.1TTL11_HUMANC9orf148TTLL11 intronic transcript 1TTLL11-IT1

For any hypothetical drugs targeting TTLL11: - Inhibition would likely reduce polyglutamylation of microtubules, possibly impairing mitotic spindle function, chromosome segregation, and ciliary activity. - Activation or upregulation could increase microtubule polyglutamylation, impacting cell division and cytoskeleton integrity.