Tubulin tyrosine ligase-like protein 9 (TTLL9)

Tubulin tyrosine ligase-like protein 9 (TTLL9) is a probable tubulin polyglutamylase enzyme that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin proteins[1][5]. This enzymatic modification, known as polyglutamylation, primarily affects microtubule structure and function, contributing to cellular processes such as flagellated sperm motility and the establishment of microtubule heterogeneity, especially within motile cilia[1][5][6]. TTLL9 is most likely functionally active as part of a protein complex, as it lacks some domains necessary for autonomous activity; its closest paralog is TTLL1[1]. Diseases associated with TTLL9 include primary ciliary dyskinesia and urocanase deficiency[1]. TTLL9 is predicted to localize to the cytoplasm, microtubules, and motile cilia, participating in protein modification and cytoskeletal organization[1][6]. No known drugs currently target TTLL9, and there is no indication that TTLL9 is a direct therapeutic target.

Other names

Tubulin tyrosine ligase like 9C20orf125probable tubulin polyglutamylase TTLL9dJ310O13.1Tubulin--tyrosine ligase-like protein 9tubulin-tyrosine ligase-like family, member 9