Tudor domain-containing protein 12 (TDRD12)

Tudor domain-containing protein 12 (TDRD12) is a member of the tudor domain protein family and is characterized by the presence of a central helicase domain and flanking tudor domains. TDRD12 is predominantly expressed in the testis and plays a critical role in the biogenesis of secondary PIWI-interacting RNAs (piRNAs), which are essential for the silencing of transposable elements during germ cell development. In mice, TDRD12 is localized to the acrosome of spermatids and is essential for normal spermatogenesis. Mutations or deletions in TDRD12 result in male infertility due to defects in secondary piRNA production and the failure to repress retrotransposons, leading to meiotic arrest in male germ cells. TDRD12 is not considered a conventional pharmacological target, and there are currently no known drugs or approved therapeutic agents targeting this protein[1][3][4][5][6].

Other names

ECAT8FLJ13072ES cell-associated transcript 8 proteinPutative ATP-dependent RNA helicase TDRD12Tudor domain containing 12ES cell associated transcript 8TDRD12