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Tumor Angiogenesis (None)
- Target
- None
- Molecular classification
- Biological Process
01
Overview
Tumor angiogenesis is the formation of new blood vessels from pre-existing vasculature to supply nutrients and oxygen to tumors, enabling their growth and metastasis. This process is driven by pro-angiogenic factors released by tumor cells and surrounding host cells, stimulating endothelial cell proliferation, migration, and differentiation. It is essential for sustained tumor growth, metabolic support, waste removal, and facilitates metastasis. While targeting angiogenesis is a major therapeutic strategy, challenges remain due to tumor heterogeneity and adaptive resistance mechanisms.
- Other names
- NeovascularizationAngiogenesis
02
Mechanism of action
Inhibition of VEGF signaling, blockade of endothelial cell proliferation and migration
03
Biological functions
Blood vessel formationNutrient supply to tumorsOxygen delivery to tumorsTumor growthMetastasis
04
Disease associations
CancerTumor progressionMetastatic disease
05
Safety considerations
HypertensionProteinuriaThrombotic eventsWound healing complicationsResistance to anti-angiogenic therapyTumor hypoxia
06
Interacting drugs
Monoclonal antibodies targeting VEGF or its receptors
4 more in the full profile.
07
Biomarkers
VEGF levelsCirculating endothelial cellsAngiogenic factorsTumor vascularityCD31Microvessel density (MVD)
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