Tumor angiogenesis and DNA integrity

Tumor angiogenesis and DNA integrity refers to a dual-process framework in oncology rather than a specific molecular entity or receptor. Tumor angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels to supply a growing tumor with nutrients and oxygen, a process primarily driven by factors like Vascular Endothelial Growth Factor (VEGF). DNA integrity involves the complex mechanisms of DNA repair and the maintenance of genomic stability, which are frequently compromised in cancer cells to facilitate rapid mutation and adaptation. These two processes are biologically linked; for example, hypoxia (a driver of angiogenesis) can impair DNA repair efficiency, and certain regulatory proteins like p53 and HIF-1α influence both pathways. Therapeutic strategies often aim to simultaneously starve the tumor of its blood supply while inducing or exploiting defects in DNA repair to achieve synthetic lethality. Because this term describes a set of biological functions and pathways rather than a single protein, enzyme, or receptor, it is classified as a functional category or process rather than a canonical therapeutic target.

Other names

Angiogenesis and DNA repair pathwayTumor vascularization and genomic stabilityVascularization and DNA maintenance

This entry refers to a combination of biological processes rather than a single molecular target. Drugs associated with these processes typically work by inhibiting pro-angiogenic signaling (e.g., via the VEGF pathway) or by disrupting DNA replication and repair mechanisms (e.g., via PARP inhibition or DNA cross-linking).