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Target intelligence / Profile preview
Tumor antigen (HLA-A24 restricted)
- Molecular classification
- Peptide/MHC Class I Complex, Tumor-associated antigen
01
Overview
A tumor antigen (HLA-A24 restricted) refers to any tumor-associated or tumor-specific peptide antigen that is presented on the surface of cancer cells in the context of the HLA-A24 major histocompatibility complex class I molecule. These antigens are recognized by CD8+ cytotoxic T lymphocytes (CTLs), enabling targeted immune responses against tumor cells expressing both the antigen and HLA-A24. Example epitopes include: CYAGSGCPL (Mam-A), LYSDPADYF/NYARTEDFF (PSMA), LLMWITQCF (NY-ESO-1), and others found in cancers like breast, prostate, pancreatic, and colorectal.
- Other names
- HLA-A24 restricted tumor antigenTumor-associated antigen (HLA-A24)HLA-A*2402 restricted tumor epitope
02
Mechanism of action
Presentation of tumor-specific peptides on HLA-A*2402 molecules, leading to activation and cytotoxicity of CD8+ T lymphocytes.
03
Biological functions
T cell activationAntigen presentationImmune responseTumor cell recognition
04
Disease associations
Cancer
05
Safety considerations
Off-target toxicityAutoimmunityCytokine release syndrome
06
Interacting drugs
Peptide vaccines
1 more in the full profile.
07
Biomarkers
HLA-A*2402 allele presenceTumor antigen expression levelCD8+ T cell response to specific peptide
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