Tumor antigen expression enhancement

Tumor antigen expression enhancement refers broadly to approaches that increase the amount, diversity, or immunological visibility of tumor antigens—particularly neoantigens—on cancer cell surfaces. This can involve altering transcriptional, post-transcriptional, or post-translational processes to generate more immunogenic peptides, modifying antigen processing/presentation pathways (e.g., increasing MHC expression), or inducing mutations that create novel antigens. These strategies are fundamental to cancer immunotherapy, including vaccines and adoptive T cell therapies, because tumors often evade immune detection by downregulating antigen presentation[4]. "Tumor antigen expression enhancement" is not a single molecular target, but an actionable concept involving multiple molecular targets and pathways in cancer biology.

Other names

Tumor antigen upregulationEnhanced tumor antigen presentationNeoantigen presentation enhancement