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Target intelligence / Profile preview
Tumor Antigen-Specific T-Cell Receptor (TCR)
- Target
- TCR
- Molecular classification
- Receptor
01
Overview
A tumor antigen-specific T-cell receptor is a heterodimeric protein complex found on the surface of T lymphocytes that enables these immune cells to recognize and respond to specific antigens presented by tumor cells. These receptors are engineered or naturally selected for their ability to bind peptides derived from tumor-associated or tumor-specific antigens, which are displayed on major histocompatibility complex (MHC) molecules on the surface of cancer cells.
02
Mechanism of action
Binding to peptide-MHC complex, T-cell activation, cytotoxicity against target cancer cells
03
Biological functions
Immune responseSignal transductionT-cell activationAntigen recognition
04
Disease associations
Cancer
05
Safety considerations
Off-target toxicity due to cross-reactivity with self-peptidesRequires precise matching between patient HLA type and targeted peptide-MHC combination
06
Biomarkers
CXCL13CD200ENTPD1Convergent TCR sequences
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