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Target intelligence / Profile preview
Tumor-Associated Antigen (HLA-A2 Restricted)
- Molecular classification
- Peptide, Antigen, MHC Class I-presented antigen
01
Overview
A tumor-associated antigen (TAA) that is HLA-A2 restricted refers to a peptide or protein fragment derived from a tumor cell that is presented on the cell surface in complex with the human leukocyte antigen A2 (HLA-A2). These antigens are recognized by cytotoxic T lymphocytes (CTLs) only when presented in the context of HLA-A2, enabling targeted immune responses against tumor cells expressing both the antigen and HLA-A2. Examples include peptides derived from proteins such as MUC1, heparanase (Hpa), TAL6, and STEAP1.
- Other names
- HLA-A2 restricted TAAHLA-A*02:01-restricted tumor antigen
02
Mechanism of action
Presentation of tumor-derived peptides by HLA-A*02:01 molecules on tumor cells, leading to activation and cytotoxic activity of HLA-A2-restricted CD8+ T cells.
03
Biological functions
Antigen presentationT cell activationImmune responseTumor cell recognition
04
Disease associations
CancerImmune evasion
05
Safety considerations
Off-target effectsAutoimmunityCytokine release syndromeTumor lysis syndromeLimited efficacy in HLA-A2 negative patients
06
Interacting drugs
Peptide vaccines
1 more in the full profile.
07
Biomarkers
HLA-A*02:01 statusTAA expression level in tumorPresence of TAA-specific T cellsMUC1 expressionHeparanase (Hpa) expressionTAL6 expressionSTEAP1 expression
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