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Target intelligence / Profile preview
Tumor-associated antigen 791Tgp72
- Molecular classification
- Glycoprotein
01
Overview
Tumor-associated antigen 791Tgp72 is a cell surface glycoprotein overexpressed in various human tumors, particularly colorectal cancers. Also known as CD55 or Decay-Accelerating Factor (DAF), it regulates the complement system and contributes to immune evasion by tumor cells. It is a target for cancer immunotherapy and diagnostic applications.
- Other names
- CD55Decay Accelerating Factor (DAF)
02
Mechanism of action
Induction of cellular immune responses against tumors expressing 791Tgp72/CD55
03
Biological functions
Complement regulationImmune evasion
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to expression in some normal tissuesRisk of immune-related adverse events
06
Interacting drugs
mAb105AD7
1 more in the full profile.
07
Biomarkers
791Tgp72/CD55 expression levels in tumor tissue
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