Tumor-associated antigen-expressing malignant cell (null)

Tumor-associated antigen-expressing malignant cells refer to cancer cells that display higher levels of specific proteins or other molecules known as tumor-associated antigens (TAAs) on their surfaces. While these antigens are elevated in cancers, they can also be present at lower levels on some normal cells. Targeting these cells is the basis of several immunotherapeutic strategies, including antibodies, CAR-T cells, and vaccines. However, not all TAAs are tumor-specific, leading to potential safety and efficacy challenges. This term does not denote a specific gene or protein but rather any malignant cell with TAA expression, which can vary widely depending on tumor type and antigen

Other names

Tumor-associated antigen-positive malignant cellTAA-expressing cancer cellTAA+ tumor cell

Immune-mediated destruction of TAA-expressing cells, such as cytotoxic T lymphocyte activation, antibody-dependent cellular cytotoxicity, and vaccine-stimulated immunity