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Target intelligence / Profile preview
Tumor-associated antigen GM2 (GM2)
- Target
- GM2
- Molecular classification
- Ganglioside, Glycosphingolipid, Tumor-associated antigen (TAA)
01
Overview
Tumor-associated antigen GM2 is a membrane glycolipid highly expressed across several aggressive cancers but minimally present on healthy tissue. It plays critical roles in promoting tumor progression through enhanced migration/invasion capabilities, angiogenesis induction, immune evasion mechanisms, and modulation of key signaling pathways. Targeted immunotherapies—including monoclonal antibodies and CAR-T technologies—are under investigation due to the favorable expression profile and functional importance of this molecule within the tumor microenvironment.
- Other names
- GalNAcβ1→4(NeuAcα2→3)Galβ1→4Glc→Cer
02
Mechanism of action
Anti-metastatic effects by inducing apoptosis in tumor cells
03
Biological functions
Cell adhesionSignal transductionRegulation of migration/invasionAngiogenesisImmunosuppression
04
Disease associations
CancerSmall-cell lung cancer (SCLC)MelanomaNeuroblastoma
05
Safety considerations
Potential for off-tumor toxicity, although appears lower than GD2 targetsNeurotoxicity
06
Interacting drugs
BIW-8962
1 more in the full profile.
07
Biomarkers
GM2 expression level (prognostic)
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