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Tumor-Associated Antigen Peptide-HLA Complexes (TAA-pHLA Complexes)
- Target
- TAA-pHLA Complexes
- Molecular classification
- Peptide-MHC Complex, Cell Surface Antigen
01
Overview
Tumor-associated antigen (TAA) peptide-HLA complexes are molecular structures formed when short peptides, derived from proteins that are overexpressed or uniquely expressed in tumor cells, are presented on the cell surface by human leukocyte antigen (HLA) molecules. These complexes play a central role in immune recognition of cancer cells and serve as critical targets for immunotherapies such as T-cell-based therapies and TCR-mimic antibodies.
- Other names
- Tumor-specific pHLACancer Peptide-HLA ComplexTumor Antigen-MHC Complex
02
Mechanism of action
Targeted recognition and killing of tumor cells by T-cells, antibody-dependent cell-mediated cytotoxicity (ADCC) via TCR-mimic antibodies.
03
Biological functions
Antigen PresentationT-cell ActivationImmune RecognitionTarget for Cytotoxic T Lymphocytes (CTLs)
04
Disease associations
CancerTumor Immunology
05
Safety considerations
Off-target toxicity due to pHLA expression in normal tissuesCytokine release syndrome (CRS)On-target, off-tumor toxicity
06
Biomarkers
pHLA density on tumor cellsT-cell infiltrationExpression of target TAA
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