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Tumor-associated antigen recognized by BrE-3 monoclonal antibody
- Molecular classification
- Mucin, Glycoprotein
01
Overview
The tumor-associated antigen recognized by the BrE-3 monoclonal antibody is a specific epitope found on an epithelial glycoprotein mucin, commonly referred to as breast epithelial mucin. This antigen is highly expressed in certain cancer cells, particularly those of breast origin. Radiolabeled antibodies targeting this antigen are used in radioimmunotherapy to deliver cytotoxic radiation doses to tumor cells.
- Other names
- Breast epithelial mucinEpithelial glycoprotein mucinBrE-3 antigen
02
Mechanism of action
Selective delivery of beta radiation to tumor cells expressing the BrE-3 antigen
03
Biological functions
Cell signalingProtection of epithelial surfacesModulation of immune responsesTumor progression
04
Disease associations
CancerBreast cancer
05
Safety considerations
Off-target effects of radiolabeled antibodiesRadiation toxicity
06
Interacting drugs
Yttrium Y 90-BrE-3
07
Biomarkers
BrE-3 antigen expression levels in breast carcinoma cells
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