Tumor-associated antigen via innate immune activation

Tumor-associated antigens (TAAs) are molecules produced by tumor cells that can be recognized by the immune system. Innate immune activation plays a pivotal role in initiating and shaping adaptive responses against these antigens. When tumors undergo stress, injury, or cell death, they release molecular patterns that activate innate immune sensors, leading to the recruitment and activation of antigen-presenting cells (APCs), which then present TAAs to T cells and stimulate adaptive immunity. Key pathways include PRRs like TLRs and RLRs, the STING pathway, and type I interferons. Cellular players include dendritic cells, natural killer cells, and macrophages. Understanding this interplay has led to new immunotherapeutic strategies like STING agonists and combination therapies with checkpoint inhibitors.

Other names

TAA-mediated innate immune responseTumor antigen presentation by APCsInnate sensing of tumor antigens

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