Target intelligence / Profile preview

Tumor-Associated Antigens (TAAs)

Target: TAAs
Molecular classification: Protein, Glycoprotein, Oncofetal Antigen, Cancer-Testis Antigen, Differentiation Antigen

Overview

Tumor-associated antigens (TAAs) are molecules, typically proteins or glycoproteins, that are present at elevated levels on the surface of tumor cells but can also be found at lower levels on some normal cells. They serve as targets for immune recognition and immunotherapeutic strategies. Because they are also present on healthy tissue, there is a risk of autoimmunity when targeting these molecules therapeutically. Common examples include HER2/neu, PSA, CEA, MAGE family, and AFP.

Other names: Tumor associated antigensTAA

Mechanism of action

Stimulation of immune response (T-cell activation, antibody-mediated cytotoxicity) against tumor cells expressing TAAs.

Biological functions

Immune recognitionAntigen presentationCell proliferation (tumor cells)Diagnostic marker

Disease associations

Cancer

Safety considerations

Autoimmunity (due to presence of TAAs in normal tissues)Off-target effects (due to shared expression with healthy tissue)Immune-related adverse events

Interacting drugs

Cancer vaccines

2 more in the full profile.

Biomarkers

HER2/neu (Breast cancer)PSA (Prostate cancer)CEA (Colorectal & other cancers)MAGE family (Melanoma)AFP (Liver cancer)

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