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Tumor-Associated Antigens (Melanoma) (None)
- Target
- None
- Molecular classification
- Protein, Peptide, Tumor-Associated Antigen, Cancer/Testis Antigen, Differentiation antigen
01
Overview
Tumor-associated antigens in melanoma are molecules—often proteins or peptides—overexpressed or aberrantly expressed by melanoma cells, but not, or only at low levels, by normal tissues. These antigens can be intracellular or presented on the cell surface and are recognized by the immune system as abnormal, potentially triggering an immune response. Melanoma TAAs play a role in diagnosis, prognosis, and as targets for immunotherapy. Examples include MAGE-A, MART-1, gp100, and Tyrosinase.
- Other names
- Melanoma Tumor-Associated AntigensMelanoma-associated antigensTAAs (Melanoma)Cancer/Testis Antigens (Melanoma)
02
Mechanism of action
Checkpoint inhibition (CTLA-4, PD-1)
03
Biological functions
Immune recognitionAntigen presentationTumor cell growth and survival
04
Disease associations
MelanomaCancerImmune evasion
05
Safety considerations
Off-target effects of immunotherapyAutoimmunityCytokine release syndrome
06
Interacting drugs
Ipilimumab
4 more in the full profile.
07
Biomarkers
Antibody levels against TAAsMAGE-A expressionMART-1 expressiongp100 expressionTyrosinase expression
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